Grey's Anatomy Texas Spinoff Set for 2027 Premiere: Plot, Cast, and More

ABC is launching a new Grey's Anatomy spin-off set in rural West Texas, focusing on a medical team at a local center, aiming for a midseason 2027 premiere. | Hollywood

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ABC is expanding the world of Grey's Anatomy with a new spin-off based in Texas, set to premiere in 2027. The untitled drama comes from Shonda Rhimes and Meg Marinis, and will be the fourth series in the Grey's Anatomy universe.

The show is set in rural West Texas and will focus on a medical team working at a rural medical center, blending emergency medicine, emotional personal stories, and isolated healthcare challenges related to rural America.

The Texas drama will introduce an entirely new group of doctors and medical staff, with Ellen Pompeo serving as an executive producer. While the cast has not been officially announced, there is a possibility of crossover appearances from existing Grey's Anatomy stars.

The spin-off is currently scheduled for a midseason 2027 premiere on ABC as part of the 2026-27 season, with no official trailer or teaser released yet.