Thousands marched in La Paz demanding President Rodrigo Paz's resignation, defying warnings of a potential military deployment.
Protestors, including miners, teachers, and transport workers, called for an end to Paz's economic reforms, which they claim will destroy the country.
Police used tear gas to disperse demonstrators trying to reach the government palace, while Paz accused protesters of being 'narcoterrorists'.
The economic damage from the blockades has exceeded $1.2 billion, with shortages of food, fuel, and medicine growing more severe.
Main unions have rejected the government's calls for dialogue, citing the protection of the constitution.